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In the biggest upset of the tournament to this point, No. 10 Creighton knocked off No. 2 Iowa on the Hawkeyes’ home floor, sending Caitlin Clark and Iowa home while advancing to the first Sweet 16 in the program’s history.

The game-winning shot for Creighton came from a familiar face for the Hawkeyes — guard Lauren Jensen hit a three-pointer with 12 seconds remaining to put the Bluejays ahead, 63-62. Jensen played for Iowa a year ago and transferred to Creighton in search of more playing time; she scored nine of Creighton’s last 10 points.

Iowa had two chances to win late, but Clark missed a layup and, after Creighton split a pair of free throws, Monika Czinano missed a layup off a post-up. The Bluejays advanced to the Sweet 16, where they’ll meet either No. 3 Iowa State or No. 6 Georgia.

“We had nothing to lose in this game,” Jensen said in a postgame TV interview. “We played well all season, we believed in each other.”

Creighton led, 23-17, after the first quarter, making five three-pointers in the opening quarter. Creighton led for almost three quarters, going ahead by as much as 12 in the second quarter, until a pair of Gabbie Marshall three-pointers gave the Hawkeyes a 56-54 lead in the fourth quarter with 6:51 remaining.

It seemed like Iowa would pull away late, but the Hawkeyes couldn’t hit enough shots and Creighton took advantage, cutting into their lead and eventually winning.

Creighton finished with 10 three-pointers for the game, with none bigger than Jensen’s, the 10th and final, at the end. The Bluejays have now upset two higher seeds, after knocking off No. 7 Colorado in the opening round

Clark finished with a season-low 15 points and didn’t make a shot in the second half. Czinano, the country’s leader in field goal percentage, scored 27 points on 12-of-20 shooting.

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